Synthetic biology promises to leverage engineering principles to enable model-based design of genetic circuits. To be successful, advancements are needed in both experimental and computational methods to support this new approach. This paper focuses …
Uropathogenic Escherichia coli (UPEC) represent the predominant cause of urinary tract infections (UTIs). A key UPEC molecular virulence mechanism is type 1 fimbriae, whose expression is controlled by the orientation of an invertible chromosomal DNA …
This paper presents a decomposition-based method for timed circuit design that is capable of significantly reducing the cost of synthesis. In particular, this method synthesizes each output individually. It begins by contracting the timed signal …
This paper proposes applying a logic synthesis approach to high level synthesis from SpecC specifications to timed asynchronous gate-level circuits. The state-based logic synthesis is used to allow for global and timing optimization. In order to …
This paper presents a new approach to two-level hazard free sum-of-products logic minimization. No currently available minimizers for single-output literal-exact two-level hazard-free logic minimization can handle large circuits without synthesis …
This paper presents a new approach to two-level hazard-free logic minimization in the context of extended burst-mode finite state machine synthesis targeting generalized C-elements (gC). No currently available minimizers for literal-exact two-level …
This paper presents a new timing analysis algorithm for efficient state space exploration during the synthesis of timed circuits or the verification of timed systems. The source of the computational complexity in the synthesis or verification of a …